Neurons Use Viruses to Share Information and Learn

When genes are activated, the instructions encoded within their DNA are first transcribed into a related molecule called RNA. Shepherd’s colleague Elissa Pastuzyn showed that the Arc shells can enclose RNA and move it from one neuron to another. And that’s basically what retroviruses do—they use protein shells to protect their own RNA as it moves between cells in a host. So our neurons use a repurposed viral gene to transmit genetic information between each other in an oddly virus-like...

 Error Catastrophe

The central problem for any theory of the origin of replication is the fact that a replicative apparatus has to function almost perfectly if it is to function at all. If it does not function perfectly, it will give rise to errors in replicating itself, and the errors will accumulate from generation to generation. The accumulation of errors will result in a progressive deterioration of the system until it is totally disorganized. This deterioration of the replicative apparatus is called the "e...

 Vestigial GLO Pseudogene

And the evolutionary prediction that we’ll find pseudogenes has been fulfilled—amply. Virtually every species harbors dead genes, many of them still active in its relatives. This implies that those genes were also active in a common ancestor, and were killed off in some descendants but not in others. Out of about 30,000 genes, for example, we humans carry more than 2,000 pseudogenes. Our genome—and that of other species— are truly well populated graveyards of dead genes. The most fam...